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Recombinant Syphilis Antigens - 4/27/2016

 

 
 
 
 
 
 
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Recombinant Syphilis Antigens
Including novel Tp0453 - an outer-membrane protein with >99% sensitivity and specificity

Syphilis is a sexually transmitted bacterial infection caused by the bacterium Treponema pallidum. It causes a systemic infection with symptoms that vary depending on the stage of the disease (primary, secondary, latent or tertiary).

Several highly immunogenic lipoproteins have been identified as diagnostic targets throughout all stages of a syphilis infection, including Tp17, Tp15, Tp41, Tp44.5 (TmpA), Tp47, Tp35 (TmpC) and Tp0453. Specifically, early immune responses have been shown to be against Tp47 and some of the flagellar proteins, followed by Tp15 and Tp17.

The novel diagnostic marker Tp0453 has demonstrated very high sensitivity and specificity compared to other markers across all stages of the disease (Cameron et al. (2003). Journal of Clinical Microbiology. 41(8):3668-74). It is proposed to be the most accurate single marker for syphillis, and does not need to be used in combination with other markers. Its superior performance is thought to be due to (1) its surface exposure as an outer-membrane protein (as opposed to an internal protein) which enables it to be continuously exposed to the immune system and (2) its lack of homologs in other bacteria such as spirochete diseases that can cause cross-reactions.

MERIDIAN SYPHILIS ANTIGENS (produced in E.coli)

Tp0453
9538 Full length, protein (a.a. 30-287), His tag, MW 30 kDa
Stand-alone marker for all stages of syphillis (primary, secondary and tertiary)
Tp15
R8A101
R01531
Full length protein, ß-gal tag
Partial protein, His tag, MW 19 kDa
Tp17
R01528
R01583
ß-gal tag, MW 137 kDa
GST and His tag, calculated MW 46.6kDa
Tp41
R01529 Full length protein, ß-gal tag, MW 153 kDa
Tp47
R8A403
R01568
Full length protein, ß-gal tag
Mosaic protein, His tag, MW ~45 kDa
TmpA (Tp44.5)
R8A404
R01530
Full length protein, ß-gal tag
A.A. 23-41 and 288-325, GST tag, MW 32 kDa
 
 
 

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Download more information on our Syphilis reagents CLICK HERE

 
 
 

New Zika Antigens for Lateral Flow

Recombinant (Sf9) antigens that work as a pair in lateral flow assays to detect Zika NS1 protein and the Zika Envelope protein.
> Learn more

 
 
 

Animal IgG for Blocking

High-quality, purified animal (goat, rabbit, sheep, rat and mouse) IgGs manufactured under a stringent quality control system following cGMP guidelines suitable for use as a passive heterophilic (HA) blocker to reduce interference and false results.
> Learn more

 
 
 

HIV Antigens for 4th Generation Combo Assay

Recombinant (E. coli) antigens highly suited for use in HIV Ag/Ab combo immunoassays, including chimeric antigens for HIV-1 gp41/gp120 and individual antigens for HIV-1 p24, HIV-1 gp41 and HIV-2 gp36.
> Learn more

 

 

Meet us at our next conference!

Immunology 2016 Booth #2611
13-17th May
Seattle, Washington

> Request a meeting

AACC 2016 - Booth #3512
31 July–4th August
Philadelphia, Pennsylvania

> Request a meeting

 
 

 

 
 
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