Reagents to Improve IgM Detection
IgM antibodies are the first type of antibody produced by the immune system in response to an infection. Consequently, lgM detection assays have proven to be valuable diagnostic tools that assist in identifying early and recent infections.
However, lgM antibodies only comprise 5% to 10% of all the antibodies in the body. In contrast, lgG antibodies which are the most abundant immunoglobulin, comprise about 75% to 80%. In order to ensure an lgM assay is both sensitive and specific, it is necessary to reduce assay interference, especially from the more plentiful lgG antibodies and other non-specific proteins, such as rheumatoid factors (RF).
Meridian offers two products that are specifically designed to enhance IgM assay performance:
IgG Absorbent, Cat# L15406G
A purified goat anti-human IgG (GAH IgG Fc) Fc fragment designed for the removal of human IgG and IgG/rheumatoid factor (RF) complexes from serum prior to testing for specific IgM antibodies.
IgM Assay Diluent, Cat# 8120
A serum diluent formulated to reduce assay interference from a patient’s IgG antibodies, rheumatoid factor, heterophilic antibodies, and other non-specific proteins that can affect the immunoassay results.
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