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New Chimeric HCV Antiges for LF - 6/12/2015


JUNE 2015




New Chimeric HCV Antigens for Lateral Flow
HCV Core/NS3/NS4/NS5 antigen pairs

Hepatitis C virus (HCV) is an infectious disease that primarily affects the liver. It is the most serious type of hepatitis virus and can lead to cirrhosis and liver failure or cancer. It is estimated that 150–200 million people, or about 3% of the world’s population, are living with chronic HCV.

The HCV genome encodes for a polyprotein of slightly more than 3000 a.a. (depending on the HCV genotype) and contains both structural (core, E1, E2) proteins and non-structural (NS2, NS3, NS4B, NS5A and NS5B) proteins. Research has shown that HCV core, NS3, NS4 and NS5 are markers of chronic HCV infection and many commercial diagnostics employ these recombinant antigens in HCV antibody detection assays.

Meridian’s new chimeric HCV core/NS3/NS4/NS5 antigens are specifically designed for use as pairs in a lateral flow or ELISA antibody detection assays. Produced in E.coli, these antigens contain different regions of core, NS3, NS4, and NS5 fragments and they can pair in double antigen assays.

R01599 HCV Core/NS3/NS4/NS5 Recombinant
• Molecular weight of 33 kDa
• Contains four antigens expressed in E. coli in a chimera:
  - HCV Core Fragment (a.a. 11-45)
  - HCV NS3 Fragment (a.a. 1208-1430)
  - HCV NS4 Fragment (a.a. 1885-1923)
  - HCV NS5 Fragment (a.a. 2332-2423)

R01600 HCV Core/NS3/NS4/NS5 Recombinant
• Molecular weight of 71 kDa
• Contains four antigens expressed in E. coli in a chimera:
  - HCV Core Fragment (a.a. 11-53)
  - HCV NS3 Fragment (a.a. 1210-1450, 1337-1483)
  - HCV NS4 Fragment (a.a. 1888-1925)
  - HCV NS5 Fragment (a.a. 2332-2423)

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New HCV Core pairs

New high sensitivity and specificity pairs for detecting HCV core antigen by ELISA or other EIA assays.
> Learn more



New Malaria Antigens

New recombinant antigens for Malaria HRP-2, pLDH, and pAldoase. Ideal antigens for lateral flow assays.
> Learn more



New Neisseria gonorrhoeae MAbs

Three new MAbs that are reactive with N. lactamica, N. meningitidis and 9 strains of N. gonorrhoeae. Proven for use in ELISA and IFA assays.
> Learn more



Meet us at our next conference!

American Association of Clinical Chemistry (AACC)
Booth # 1050, Hall 82
July 27th-30th, 2015
Atlanta, Georgia

> Request a meeting