Mycoplasma pneumonia (M. pneumonia) is a contagious respiratory infection that causes regular epidemics. Diagnosis most frequently relies on rapid, single-specimen, serological tests which typically detect IgG and/or IgM antibodies to M. pneumoniae.
Although PCR assays are now readily available for M. pneumoniae diagnosis, they have been shown to have a lower sensitivity than rapid tests. They also may over estimate the clinical importance of M. pneumoniae as a pathogen since these assays indiscriminately detect both healthy carriers of M. pneumoniae and infected individuals. Given M. pneumoniae often cocirculates with other bacterial and viral respiratory pathogens, it is important to accurately diagnose the active infectious agent to provide the correct treatment. For these reasons, research has shown that serologic assays and molecular-based tests should both be used for maximum diagnostic accuracy.
Meridian offers new antibody pairs for Mycoplasma pneumoniae. These antibodies are specific for the P1 adhesin protein and do not cross-react with other mycoplasma species.
Zhang, L. et al. PCR versus serology for diagnosing Mycoplasma pneumoniae infection: A systematic review & meta-analysis. Indian J Med Res. 2011 Sep; 134(3): 270–280.
Dorigo-Zetsma, J. W. et al. Comparison of PCR, Culture, and Serological Tests for Diagnosis of Mycoplasma pneumoniae Respiratory Tract Infection in Children. J. Clin. Microbiol. 1999Jan; 37(1):14-17.