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LH

Luteinizing hormone (LH) is a gonadotropic hormone that is produced by the pituitary gland and operates in conjunction with FSH to drive puberty, menstruation and fertility. A surge in LH levels triggers ovulation and the development of the corpus luteum in females, and in males it causes the Leydig cells to release testosterone.

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LH Products (11)

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Name Type Format Host/Source Isotype Tested Apps Unit Catalog SDS COA Request Sample
LH >= 98% Pure Antigen Purified Human N/A CC MG A01687H View SDS View COA Order A Sample
LH Recombinant Antigen Purified Mammalian Cells N/A CLI UT R01715 View SDS View COA Order A Sample
MAb to LH Monoclonal Purified Mouse IgG1,k EIA,Pr MG MDF07-037 View COA Order A Sample
MAb to LH Monoclonal Purified Mouse IgG1,k EIA,Pr MG MAF07-412 View SDS View COA Order A Sample
MAb to LH Monoclonal Purified Mouse IgG1,k EIA,Pr MG MAF07-226 View SDS View COA Order A Sample
MAb to LH Monoclonal Purified Mouse IgG1,k EIA,Pr MG MAF07-037 View SDS View COA Order A Sample
MAb to LH Monoclonal Purified Mouse IgG2a,k EIA,Pr MG MAF07-036 View SDS View COA Order A Sample
MAb to LH Beta Monoclonal Purified Mouse IgG1 EIA,Pr MG E92402M View SDS View COA Order A Sample
MAb to LH Beta Monoclonal Purified Mouse IgG1 Pr,EIA MG E92120M View SDS View COA Order A Sample
MAb to LH, Beta Monoclonal Purified Mouse IgG EIA,Pr,WB MG E86124M View SDS View COA Order A Sample
Goat anti Human LH Polyclonal Neat Goat N/A RIA ML D10295G View SDS View COA Order A Sample

Luteinizing hormone (LH)

High levels of luteinizing hormone can indicate a problem with infertility as the hormone directly impacts the reproductive system. In women, LH levels that are too high are often connected to polycystic ovary syndrome, which creates inappropriate testosterone levels. Some genetic conditions, like Turner syndrome or Klinefelter syndrome, can cause high levels of the hormone.

Low levels of luteinizing hormone can also cause infertility, because insufficient levels will limit the production of sperm or the ovulation process in women. LH deficiency almost always occurs in conjunction with follicle-stimulating hormone (FSH) deficiency because LH and FSH are secreted by the same pituitary gonadotrope cells. LH deficiency can manifest in females or males as delayed puberty, hypogonadism at any age, or reproductive abnormalities that can be dramatic or subtle.

Diagnosis

LH is composed of two noncovalently associated dissimilar amino acid chains, alpha and beta. The alpha chain is similar to that found in human thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG). LH diagnostic assays are useful to evaluate fertility issues, the function of reproductive organs (ovaries or testicles), or to detect ovulation. In children it can also be useful to evaluate early or delayed sexual maturation. The most sensitive LH assays on the market are monoclonal antibody based competitive-ELISAs. However, lateral flow devices using antibody sandwich-based formats are widely used for at-home ovulation tracking.

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