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New Legionella pneumophila - 11/14/2017

 

 

NOVEMBER 2017

 

New Legionella pneumophila
Antibodies and Native Antigens for Lateral Flow Assays Using Urine Specimens

 

 

Legionella products

A01715N

Legionella pneumophila
Suitable for use as a positive
  control in LF

C01952M

MAb to Legionella pneumophila LPS
Recognizes Legionella pneumophila
  lipopolysaccharide (LPS) Serotype 1
Suitable for use in LF
Works with urine specimens

C01951M

MAb to Legionella pneumophila LPS
Recognizes Legionella pneumophila
  lipopolysaccharide (LPS) Serotype 1
Suitable for use in LF
Works with urine specimens

B65051G

PAb to Legionella pneumophila
Recognizes all antigens of
  intact microorganism
Suitable for use in LF & IFA
Works with urine specimens

Pairing Information

For use in lateral flow assay with urine as the specimen

Capture

Detection

Native Antigen

 

C01951M

C01952M

A01715N

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> Respiratory Diseases

 
 

Legionella pneumophila is a gram-negative bacteria typically found in natural and artificially hydrated environments. L. pneumophila serotype 1 is the most common serotype and causes a systemic infection called Legionnaires' disease that leads to pneumonia. The disease is very treatable with antibiotics especially if it is diagnosed quickly.

L. pneumophila antigen detection in urine is the preferred initial test for Legionnaires' disease because it is rapid, relatively inexpensive, and practical. Typical performance of these tests are 70% sensitivity and close to 100% specificity. Test sensitivity can be improved if urine samples are concentrated by ultrafiltration and obtained within 7 days of the onset of pneumonia.

The only limitation of urinary antigen testing is that it detects only L. pneumophila serogroup 1. However, because this serogroup causes most cases of Legionnaires' disease, the test is recommended strongly as part of the workup. Serologic assays are not helpful in clinical decision making but are valuable for epidemiologic studies. PCR assays to detect Legionella DNA in urine, BAL fluid, and serum samples have been used. Although commercial kits are available, the test is not widely used.

 

 

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