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Vitamin D - 10/2/2017
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Vitamin D
New Antibodies and Antigens for Assay Development



Antibody/Antigen Pairing (for Competitive Assays)
K01214M A01697B Lateral Flow
K01214M A01698B ELISA and RIA

Monoclonal Antibodies
K24123M MAb to 1,25 Dihdroxy Vitamin D3 
K24124M MAb to 25 OH Vitamin D3
Also available as a liquid (K24124M-LQ)
K01214M MAb to 25 OH Vitamin D2 & D3
K01213M MAb to 25 OH Vitamin D2 & D3

A50674H Vitamin D Binding Protein (Gc-Globulin)
 Native antigen from human plasma
 Purified, > 95% pure (SDS-PAGE)
A01694D 25 OH Vitamin D3 BSA Conjugate
 BSA, ≥ 99% Pure (HPLC)
A01409H 1,25 Dihydroxy Vitamin D3
Purified, >99% pure (HPLC)
A01698B Vitamin D Derivative Biotin
• Biotin conjugated
• Chemically manufactured
• >95% pure (HPLC)
• Lyophilized
A01697B Vitamin D Derivative BSA
• BSA conjugated
• Chemically manufactured
• Liquid




Vitamin D is a fat-soluble precursor of the steroid hormone calcitriol that is essential for bone health and mineral metabolism.

To become biologically active Vitamin D is modified to 25-hydroxyvitamin D (25 OH Vitamin D3 or Calcidiol) and 1,25 dihydroxyvitamin D (Calcitriol). A total Vitamin D assay measures the level of Vitamin D in both forms.

Serum 25 OH Vitamin D3 (calcidiol) is the most stable circulating form of vitamin D and a low blood level suggests that a person is not getting enough exposure to sunlight or enough dietary vitamin D. Vitamin D deficiency, if severe, can lead to rickets (children) or osteomalacia (adults) and is linked to hyperparathyroidism, osteoporosis, and muscle weakness/pain. Prolonged vitamin D insufficiency leads to increased risk for multiple chronic conditions, including anemia, cardiometabolic and autoimmune diseases, depression, neurodegenerative/cognitive and sleep disorders, and some cancers.

1,25-Dihydroxy Vitamin D3 (Calcitriol) regulates the expression of hundreds of genes and triggers signaling cascades in many tissues and organs. A low level of 1,25-Dihydroxy Vitamin D3 can be seen in kidney disease and is one of the earliest changes to occur in persons with early kidney failure. A high level of 1,25-Dihydroxy Vitamin D indicates the presence of excess parathyroid hormone since PTH is essential for vitamin D activation.

Vitamin D screening is recommended for high risk groups such as patients with or at risk for osteoporosis, patients with rickets/osteomalacia, chronic kidney disease and malabsorption syndrome.



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October 29 - November 1, 2017
Yunnan Sheng, CHINA

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