Culture and Media Optimization
Core Virus Production Expertise
Mammalian Cell Culture |
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Meridian Life Science, Inc. has over 30 years of cell culture, virus production, protein purification, assay development, and regulatory compliance; Meridian Life Science is your trusted partner for contract R&D and process development. Meridian Life Science can work with you to develop custom diagnostic and clinical biologicals. Our capabilities include: |
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| Cell Line Development / Expression Systems: |
Cell Culture and Egg Incubation Equipment: |
- Seamless tech transfer from development to clinical production
- Experience in cell culture optimization
- Experience with Baculovirus Expression Vector System (BEVS)
- Selection of optimal clones and expression systems
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- Shaker flask
- Cell-line or culture flask
- Roller bottle
- smooth or ridged
- up to 1,500 bottles are processed weekly for diagnostic antigen production
- Spinner flask
- up to 30 liter Spinner flask
- WAVE Bioreactor
- Cell Factories: up to 40 CF10 stacks
- Egg Incubator for up to ~ 300 eggs
- Bioreactors (up to 130L)
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| Process Development Services: |
- Eukaryotic culture in roller bottles
- Eukaryotic culture in WAVE Bioreactors (up to 100L). Batch, Fed Batch and Perfusion Culture Experience
- Conversion of hybridomas for production in cell
- Media optimization
- 130L Bioreactors
- Centrifugation and filtration methods
- Viral Quantitation via plaque assay, TCID50, and end point dilution
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