Toxoplasma gondii (T. gondii), an apicomplexan parasite, is a serious complication in immunocompromised individuals such as AIDS patients and can be the cause of congenital birth defects in newborns of infected mothers.
Azurin, the cupredoxin family protein produced by Pseudomonas aeruginosa, exhibits the ability to impede invasion of a number of diverse intracellular pathogens.
Examples of pathogens that are blocked by this protein:
In their publication “Azurin-Like Protein Blocks Invasion of Toxoplasma gondii through Potential Interactions with Parasite Surface Antigen SAG1” authors Arunasalam Naguleswaran et al demonstrated that azurin and azurin-like protein (Laz) is a potent inhibitor of T. gondii.
Testing included use of two Meridian Life Science products:
- Catalog # C65203M, Monoclonal Antibody to T. gondii (FITC conjugated) was used in an immunofluorescence assay.
- Catalog # R18426, T. gondii P30 (SAG1) Recombinant Protein was used in surface plasmon resonance analysis.
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